New nanoparticles to release drugs in target infection

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Researchers at WSU developed nanocarriers that have unique stimuli-responsive property, which allows drugs to release at the site of infection.

Nanoparticles that can demonstrate stimulus response can be used to target infections causing bacteria to reduce its growth and prevent the disease. Scientists at Washington State University (WSU) have developed stimuli-responsive nanoparticles that could be used for preventing infectious diseases. The idea is to attach antibiotic and anti-inflammatory agents with the microscopic particles so that the medicines could be released as the particles reach the site of infection.

WSU scientists at the College of Pharmacy and Pharmaceutical Sciences developed a new nanoparticle and coated the material with such molecules that could enable the blood vessels to release in response to infections. The study was published in the journal Advanced Materials on September 2018.

Researchers are finding alternative and efficient method to cure sepsis, an inflammatory response causing organ failure, in the laboratory of Pharmaceutical Sciences. Assistant Professor Zhenjia Wang said: “This study not only proves a new drug delivery system but also may shift the current landscape in nanomedicine to biology-driven design of nanotherapeutics. This has the potential to improve the therapies of many more infectious diseases.”

Based on the new discovery, chemists and material engineers will be able to design new drug formulations for infectious diseases such as TB or other respiratory infection. The use of nanocarrier could carry two drugs, and deliver these drugs in a manner that waits to deploy only when it reaches the site of infectious tissues. This will help in efficient consumption of drugs, as wastages could be minimized with the usage of nancarriers.

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