Novel Antioxidant Potentially Reduces Heart Disease

Novel Antioxidant Potentially Reduces Heart Disease

Researcher reveal that novel antioxidants make old blood vessels regain its robust functionality, seeming young again, according to an article published on April 29, 2018.

Researchers from the Integrative Physiology of Aging Laboratory, University of Colorado Boulder, revealed that a new antioxidant specifically targets mitochondria and reverses age-related vascular changes by the equivalent of 15 to 20 years within six weeks.

The study shows evidence for benefits of pharmaceutical-grade nutritional supplements, or nutraceuticals, in preventing heart disease. “This is the first clinical trial to assess the impact of a mitochondrial-specific antioxidant on vascular function in humans. It suggests that therapies like this may hold real promise for reducing the risk of age-related cardiovascular disease.” Said Matthew Rossman, lead author of the study.

20 healthy men and women aged 60-79 years were considered to be part of the study. Half were given 20 milligrams of a supplement called MitoQ, per day. Antioxidant Coenzyme Q10 was chemically altered to cling to mitochondria inside cells, to produce this supplement. The other half took a placebo.

Six weeks later, researchers assessed the rate at which lining of blood vessels, or the endothelium functioned. They checked how the intensity of arteries’ dilation with increased blood flow.

Two weeks later, a wash-out period began, wherein the subjects were required to take nothing, switching the two groups and repeating the tests.

The researchers found that on taking the supplement, dilation of arteries improved by 42 percent. This made their blood vessels look more like someone aged 15 to 20 years younger. If this is sustained, associated risk of heart disease would drop by 13 percent.

Under placebo conditions participants’ arteries seemed stiffer, while supplementation reduced such stiffness.

“This study breathes new life into the discredited theory that supplementing the diet with antioxidants can improve health. It suggests that targeting a specific source-mitochondria-may be a better way to reduce oxidative stress and improve cardiovascular health with aging.” said Seals, co-author of the study.

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